About Kambo
Origin and Benefits
What is Kambo
Kambo - a process & ceremony - is created with the skin secretion, taken from the amazonian frog ´Phyllomedusa bicolor´,
also known as the ´Giant Monkey Frog´. In the indigenous tribes it is called Sapo, Daw-kit and Acate. There are many tribes
and traditions in the Amazon region and as a result, there are many names and different practices.
For the indigenous cultures in the Amazon, this purgative, immunity-boosting medicine is very important. Known as the “vaccine
of the forest,” it has also become known outside of the Amazon as a powerful treatment for many illnesses and conditions.
Kambo is a sacred practice that uses the skin secretion of the Amazonian frog Phyllomedusa bicolor, also known as the Giant
Monkey Frog. Among Indigenous tribes, it is known by names such as Sapo, Daw-Kit, and Acate. The Amazon is home to many
tribes, each with their own unique traditions and methods for working with this sacred medicine. For Indigenous cultures, Kambo
holds deep significance as a purgative and immunity-supporting medicine. Known as the “vaccine of the forest”, it is used
in traditional contexts to cleanse, strengthen, and realign body, mind, and spirit. Beyond the Amazon, Kambo has
gained recognition for its potential to support well-being, though it is essential to honor its ancestral roots and the
wisdom of those who have preserved this knowledge for generations.
Open Heart
Mental Clarity
System Reset
Detoxification
Why Kambo
One of the most profound effects of Kambo is the heart-opening. The protective layers we build around
ourselves soften, allowing us to truly feel again. Immediately after a session, we often experience a deep
innerpeace—starting in the core of the body and expanding outward, filling us with a profound sense of clarity
and balance. In the days following, decisions become clearer, energy levels rise, and many people report a noticeable
shift in theiremotional and physical well-being. Some of our guests have even shared that their doctors were
astonished by sudden improvements in their health.
Kambo is a powerful detoxifier, a reset for the entire system, helping to realign us with our natural state.
It is more than just a physical cleanse—it is a return to our center, a reconnection with ourselves.
Health Benefits
The many different peptides in the Kambo secretion have a broad spectrum of activity. The properties
of kambo peptides and Experience has shown that Kambo may have positive effects in:
- Chronic pain
- Inflammation
- Bacteria, viruses, and fungi
- AIDS\HIV
- Cancer
- Lyme disease
- Fever and infections
- Deeply rooted toxins
- Joint diseases
- Hepatitis
- Skin diseases
- Depression
- Migraines
- Blood circulation problems - Negative energies (traditionally known as “panema”)
- Alzheimer’s and Parkinson’s disease
- Vascular insufficiency
- Organ diseases
- Fertility problems
- Addiction to opiates or prescription painkillers (Kambo can reduce physical pain, thus it might help people kick their addictions to other painkillers)
Kambo is not a medically approved treatment. We do not provide medical advice or guarantee specific outcomes.
Please consult a healthcare professional if you have health concerns.
Much of these effects can be attributed to the pharmacological effects of the active
ingredients in the Kambo secretion, but frog medicine goes much further, affects all levels.
Kambo is a powerful process and should be applied by an experienced practitioner. A practitioner can
guide and support you in a kambo session. helping you to set an intention before the ceremony,
ensure proper set and setting during the session, and integration afterward.
Note: This information is provided for educational purposes only and is not intended as medical advice.
The Science Behind Kambo
Peptides and Their Effects
Kambo, the secretion of the Amazonian giant tree frog Phyllomedusa bicolor, has been the subject of scientific
research since the 1980s. Dr. Vittorio Erspamer, a pharmacologist from the University of Rome and the first to
analyze the secretion, identified a unique combination of bioactive peptides with profound effects on the human
body. These peptides interact with various systems, including the gastrointestinal tract, cardiovascular system,
and the brain's hormonal regulation centers.
The following peptides have been scientifically confirmed in Kambo secretion:
1. Phyllomedusin
Type: Tachykinin peptide
Effects: Strongly affects smooth muscles, particularly in the gastrointestinal tract. It promotes vasodilation,
lowers blood pressure, and supports the detoxification process by stimulating mucus secretions.
2. Phyllokinin
Type: Bradykinin-like peptide
Effects: Induces vasodilation and hypotension by relaxing blood vessels. It plays a significant role in Kambo's
cardiovascular effects.
3. Dermorphin
Type: Opioid peptide
Effects: Binds to mu-opioid receptors, providing potent analgesic effects that are estimated to be 20-40 times
more effective than morphine, yet with significantly lower addictive potential.
4. Deltorphin
Type: Opioid peptide
Effects: Selectively binds to delta-opioid receptors, providing pain relief more potent than many synthetic opioids.
Unlike conventional opioids, it does not create physical dependence.
5. Sauvagine
Type: CRF-like peptide (corticotropin-releasing factor)
Effects: Influences the body's response to stress by regulating hormone release in the hypothalamic-pituitary-adrenal
(HPA) axis. It also modulates water balance and body temperature.
6. Tryptophyllin
Type: Bioactive peptide
Effects: May influence insulin release and liver protein activation, supporting metabolic functions. Further research is
ongoing to clarify its role in metabolic regulation.
7. Dermaseptin
Type: Antimicrobial peptide
Effects: Exhibits strong antimicrobial activity against bacteria, fungi, and viruses. Research into its potential for antibiotic
development is ongoing.
Peptides Incorrectly Attributed to Kambo:
Adenoregulin
Found in amphibian skin secretions but not confirmed in Phyllomedusa bicolor.
Careulein
Present in other amphibians but not in Kambo secretion.
Conclusion
Kambo secretion contains a remarkable range of bioactive peptides with diverse effects on the body's systems—
from pain modulation and stress regulation to antimicrobial defense and metabolic support . The research of Dr.
Vittorio Erspamer laid the foundation for understanding these peptides' pharmacological potential, making Kambo
one of the most biochemically complex natural secretions known in amphibian species.
References:
Erspamer, V., et al. (1981). The Discovery of Bioactive Peptides in Amphibian Skin Secretions. Biochemical Pharmacology, 30(21), 2751–2763.
Erspamer, V., et al. (1985). Peptides from Amphibian Skin: Pharmacological Applications. European Journal of Pharmacology, 134(2–3), 285–299.
Zasloff, M. (1987). Antimicrobial peptides from amphibian skin: Dermaseptins from Phyllomedusa bicolor. PNAS, 84(15), 5449–5453.
Note: This information is provided for educational purposes only and is not intended as medical advice.
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